Cytokine receptor gp130 promotes postnatal proliferation of cardiomyocytes required for the normal functional development of the heart.
Kawagishi H, Nakada T, Numaga-Tomita T, Larrañaga M, Guo A, Song LS, Yamada M.
Am J Physiol Heart Circ Physiol. in press

ジャンクトフィリンによるL型カルシウムチャネル調節機構
中田 勉, 山田 充彦
日本薬理学会誌. Vol. 157 No. 1: 4-8.

NRSF-GNAO1 Pathway Contributes to the Regulation of Cardiac Ca²⁺ Homeostasis.
Inazumi H, Kuwahara K, Nakagawa Y, Kuwabara Y, Numaga-Tomita T, Kashihara T, Nakada T, Kurebayashi N, Oya M, Nonaka M, Sugihara M, Kinoshita H, Moriuchi K, Yanagisawa H, Nishikimi T, Motoki H, Yamada M, Morimoto S, Otsu K, Mortensen RM, Nakao K, Kimura T.
Circ. Res. 130(2): 234-48.

AT₁アンジオテンシン受容体の生理的機能に基づいた新たな新生児・乳児心不全治療薬の開発
川岸裕幸, 山田充彦.
日本薬理学会誌. Vol. 156 No. 6: 351-4.

βアレスチンバイアスAT1受容体アゴニストは新しい乳幼児心不全治療薬の有力候補である。
川岸裕幸, 山田充彦.
医学のあゆみ. Vol. 276 No. 12: 1137-8.

Adrenomedullin-RAMP2 and -RAMP3 Systems Regulate Cardiac Homeostasis during Cardiovascular Stress.
Cui N, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Tanaka M, Wei Y, Kakihara S, Zhao Y, Aruga K, Kawagishi H, Nakada T, Yamada M, Shindo T.
Endocrinology. 162(3):bqab001.

β-Arrestin–Biased AT₁ Agonist TRV027 Causes a Neonatal-Specific Sustained Positive Inotropic Effect Without Increasing Heart Rate.
*Kashihara T, *Kawagishi H, Nakada T, Numaga-Tomita T, Kadota S, Wolf EE, Du CK, Shiba Y, Morimoto S, Yamada M. (*Equal contribution)
J Am Coll Cardiol Basic Transl Science. 5(11):1057-1069.

Increased predominance of the matured ventricular subtype in embryonic stem cell-derived cardiomyocytes in vivo.
Ichimura H, Kadota S, Kashihara T, Yamada M, Ito K, Kobayashi H, Tanaka Y, Shiba N, Chuma S, Tohyama S, Seto T, Okada K, Kuwahara K, Shiba Y.
Sci Rep. 10(1):11883.

Increase in phospholamban content in mouse skeletal muscle after denervation.
Komatsu M, Nakada T, Kawagishi H, Kato H, Yamada M.
Journal of Muscle Research and Cell Motility. 39(5-6):163-173

Impact of chronic kidney dysfunction on serum Sulfatides and its metabolic pathway in mice.
Yamada Y, Harada M, Hashimoto K, Guo R, Nakajima T, Kashihara T, Yamada M, Aoyama T, Kamijo Y.
Glycoconjugate Journal 36(1):1-11

Prostanoid EP4 receptor-mediated augmentation of I_h currents in Aβ dorsal root ganglion neurons underlies neuropathic pain.
Zhang H, Kashihara T, Nakada T, Tanaka S, Ishida K, Fuseya S, Kawagishi H, Kiyosawa K, Kawamata M, Yamada M. 
J. Pharmacol. Exp. Ther. 368:50-58

Effects of hypertension and antihypertensive treatments on sulfatide levels in serum and its metabolism.
Guo R, Hu X, Yamada Y, Harada M, Nakajima T, Kashihara T, Yamada M, Aoyama T, Kamijo Y.
Hypertens Res. 2019 May;42(5):598-609.

Sonic hedgehog signaling regulates the mammalian cardiac regenerative response.
Kawagishi H, Xiong J, Rovira II, Pan H, Yan Y, Fleischmann BJ, Yamada M, Finkel T. 
J. Mol. Cell. Cardiol. 123:180-184

PDGF-induced migration of synthetic vascular smooth muscle cells through c-Src-activated L-type Ca²⁺ channels with full-length Ca_V1.2 C-terminus.
Guo X, Kashihara T, Nakada T, Aoyama T, Yamada M.
Pflugers Arch. 470(6):909-921

Physical interaction of junctophilin and the Ca_V1.1 C terminus is crucial for skeletal muscle contraction.
Nakada T, Kashihara T, Komatsu M, Kojima K, Takeshita T, Yamada M.
Proc. Natl. Acad. Sci. USA. 115: 4507-4512

Angiotensin II activates Ca_V 1.2 Ca²⁺ channels through β-arrestin2 and casein kinase 2 in mouse immature cardiomyocytes.
Kashihara T, Nakada T, Kojima K, Takeshita T, Yamada M.
J. Physiol. 595: 4207-4225

Transplantation of adipose tissue-derived stem cells improves cardiac contractile function and electrical stability in a rat myocardial infarction model.
Gautam M, Fujita D, Kimura K, Ichikawa H, Izawa A, Hirose M, Kashihara T, Yamada M, Takahashi M, Ikeda U, Shiba Y.
J. Mol. Cell. Cardiol. 81: 139-149

Molecular mechanism of junctional membrane-targeting of cardiac and skeletal muscle L-type calcium channels.
Nakada T, Yamada M.
Nihon Yakurigaku Zasshi. 144: 217-221

Cardiac overexpression of constitutively active Gαq causes angiotensin II type1 receptor activation, leading to progressive heart failure and ventricular arrhythmias in transgenic mice.
Matsushita N, Kashihara T, Shimojo H, Suzuki S, Nakada T, Takeishi Y, Mende U, Taira E, Yamada M, Sanbe A, Hirose M.
PLoS One. 29: e106354

Phlorizin prevents electrically-induced ventricular tachyarrhythmia during ischemia in Langendorff-perfused guinea-pig hearts.
Hirose M, Shibazaki T, Nakada T, Kashihara T, Yano S, Okamoto Y, Isaji M, Matsushita N, Taira E, Yamada M.
Biol. and Pharm. Bull. 37: 1168-1176

β₂-Adrenergic and M₂-muscarinic receptors decrease basal t-tubular L-type Ca²⁺channel activity and suppress ventricular contractility in heart failure.
Kashihara T, Hirose M, Shimojo H, Nakada T, Gomi S, Hongoe M, Yamada M.
Eur. J. Pharmacol. 724: 122-131

TRPM4 channels mediate hypertonicity-induced, Ca²⁺-impermeable, Non-selective cation currents in a cervical cancer cell line, HeLa cells.
Gomi S, Nakada T, Kashihara T, Ikeda U, Yamada M.
Shinshu. Med. J. 62: 33-44

Novel regulation of cardiac metabolism and homeostasis by the adrenomedullin-receptor activity-modifying protein 2 system.
Yoshizawa T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Iesato Y, Koyama T, Uetake R, Yang L, Yamauchi A, Tanaka M, Toriyama Y, Igarashi K, Nakada T, Kashihara T, Yamada M, Kawakami H, Nakanishi H, Taguchi R, Nakanishi T, Akazawa H, Shindo T.
Hypertension 61: 341-351

Nicorandil prevents Gα_q-induced progressive heart failure and ventricular arrhythmias in transgenic mice.
Hirose M, Takeishi Y, Nakada T, Shimojo H, Kashihara T, Nishio A, Suzuki S, Mende U, Matsumoto K, Matsushita N, Taira E, Yamada M. 
PLoS One 7: e52667

Proximal C-terminus of α_1C subunits is necessary for junctional membrane-targeting of cardiac L-type calcium channels.
Nakada T, Flucher BE, Kashihara T, Sheng X, Shibazaki T, Horiuchi-Hirose M, Gomi S, Hirose M, Yamada M.
Biochem. J. 448: 221-231

KGA-2727, a Novel Selective Inhibitor of a High-Affinity Sodium Glucose Cotransporter (SGLT1), Exhibits Antidiabetic Efficacy in Rodent Models.
Shibazaki T, Tomae M, Ishikawa-Takemura Y, Fushimi N, Itoh F, Yamada M, Isaji M.
J. Pharmacol. Exp. Ther. 342: 288-296

Two Mechanistically Distinct Effects of Dihydropyridine Nifedipine on Ca_V1.2 L-Type Ca²⁺ Channels Revealed by Timothy Syndrome Mutation.
Sheng X, Nakada T, Kobayashi M, Kashihara T, Shibazaki T, Horiuchi-Hirose M, Gomi S, Hirose M, Aoyama T, Yamada M.
Eur. J. Pharmacol. 685: 15-23

Chronic receptor-mediated activation of G_i/o proteins alters basal t-tubular and sarcolemmal L-type Ca²⁺ channel activity through phosphatases in heart failure.
Kashihara T, Nakada T, Shimojo H, Horiuchi-Hirose M, Gomi S, Shibazaki T, Sheng X, Hirose M, Hongo M, Yamada M.
Am. J. Physiol. Heart Circ. Physiol. 302: H1645-H1654